Buy Pharmaqo US RAD 140 (TESTOLONE) UK | Selective Androgen Receptor Modulator for Research

Pharmaqo US – RAD 140 (TESTOLONE) – Available Now in the UK

For researchers and scientists investigating androgen receptor biology, muscle physiology, and potential therapeutic applications, Pharmaqo US – RAD 140 (TESTOLONE) delivers a premium research-grade selective androgen receptor modulator. RAD140, also known as Testolone or Vosilasarm, is a nonsteroidal compound that binds selectively to androgen receptors, demonstrating tissue-selective agonist and antagonist activities . Originally developed for conditions including muscle wasting and hormone-sensitive breast cancer, this investigational compound has been extensively studied for its anabolic effects in muscle and bone, as well as its potential neuroprotective properties . With an elimination half-life of 45-60 hours, it offers once-daily dosing convenience for research applications . Now available from uksteroidshop.co.uk, your trusted UK-based supplier, you can access this premium research compound with the assurance of Pharmaqo US quality.

Whether you’re conducting androgen receptor research in Birmingham, studying muscle physiology in Manchester, or investigating cancer cell biology in Glasgow or Edinburgh, we deliver nationwide. Research facilities across London, Leeds, Liverpool, Bristol, Nottingham, Sheffield, Cardiff, and Belfast trust us for their advanced research compound needs. Experience the quality and consistency required for serious scientific investigation.

Why Choose uksteroidshop.co.uk for Pharmaqo US RAD 140

Premium Research-Grade Quality

Pharmaqo US is renowned for producing high-quality research-grade compounds. Every batch of Pharmaqo US – RAD 140 (TESTOLONE) meets stringent quality benchmarks, ensuring you receive a product that delivers consistent, reliable performance for your laboratory work.

Selective Androgen Receptor Modulation

RAD140 is a potent and selective androgen receptor modulator (SARM) with high affinity for the androgen receptor (Ki = 7 nM) . It shows good selectivity over other steroid hormone receptors, making it an invaluable tool for studying AR-specific biological processes .

Tissue-Selective Activity Profile

RAD140 demonstrates dissociation of effect between tissues in preclinical studies, with agonistic and anabolic effects in muscle, agonistic effects in breast, and partially agonistic or antagonistic effects in the prostate gland and seminal vesicles . This tissue selectivity is a key characteristic of SARMs and contributes to their research interest.

Extensive Research Background

RAD140 has been the subject of extensive preclinical and clinical research, with studies demonstrating its effects on:

• Muscle and bone: Promotes anabolic effects, increasing muscle mass and bone density

• Neuroprotection: Protects hippocampal neurons from cell death induced by apoptotic insults, with efficacy comparable to testosterone

• Breast cancer: Exhibits potent antitumor activity in AR/ER+ breast cancer models as both a single agent and in combination with CDK4/6 inhibitors

• AR signaling: Activates AR in breast cancer cells while suppressing ER signaling, including repression of the ESR1 gene

Authenticity Guaranteed

The market is flooded with counterfeit products, but uksteroidshop.co.uk guarantees you receive Genuine Pharmaqo US – RAD 140 (TESTOLONE). We source directly from authorised Pharmaqo US distributors to ensure you are getting the real deal, not a dangerous substitute. Every vial is verified authentic.

UK Stock Availability

Forget waiting weeks for international parcels. We maintain deep UK stock ready to ship, meaning your order is processed and dispatched promptly from within the country. When you order Pharmaqo US RAD 140 online, it ships from the UK immediately.

Secure Checkout Process

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Trusted by Researchers

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Key Product Specifications

• Compound Name: RAD140 (Testolone, Vosilasarm)

• CAS Number: 1182367-47-0

• Molecular Formula: C₂₀H₁₆ClN₅O₂

• Molecular Weight: 393.8 g/mol

• IUPAC Name: 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile

• Purity: >98% (HPLC)

• Physical Form: White to off-white solid powder

• Solubility: Soluble in DMSO (≥100 mg/mL)

• Mechanism: Selective androgen receptor modulator (SARM)

• Half-Life: 45-60 hours in humans

• Storage: -20°C (stable for ≥1 year as powder); in solvent -80°C for 6 months, -20°C for 1 month

Key Research Findings on RAD140

Androgen Receptor Binding and Selectivity

RAD140 demonstrates high affinity for the androgen receptor with a Ki value of 7 nM (relative to 29 nM for testosterone and 10 nM for DHT) . It shows good selectivity for the AR over other steroid hormone receptors, with the closest off-target receptor being the progesterone receptor (IC50 = 750 nM versus 0.2 nM for progesterone) . It also exhibits potent efficacy in terms of AR activation, with an EC50 value of 0.1 nM in the C2C12 osteoblast differentiation assay .

Tissue-Selective Activity

RAD140 shows remarkable tissue selectivity in preclinical models:

• In castrated immature male rats, RAD140 (at 10 mg/kg/day) stimulated prostate weight to 67%, seminal vesicle weight to 59%, and levator ani muscle weight to 117% compared to testosterone propionate 1 mg/kg/day

• When combined with testosterone propionate, RAD140 partially antagonized the weight increases of the prostate and seminal vesicles but was additive for levator ani muscle weight stimulation

• A dose of 0.3 mg/kg/day stimulated levator ani muscle weight similarly to non-castrated controls, while a 33-fold higher dose was required for prostate effects

Neuroprotective Effects

Research demonstrates that RAD140 exhibits significant neuroprotective properties:

• In cultured hippocampal neurons, RAD140 was as effective as testosterone in reducing apoptosis induced by β-amyloid peptide and apoptosis activator II

• RAD140 neuroprotection was dependent upon MAPK signaling, as evidenced by elevation of ERK phosphorylation and inhibition of protection by the MEK inhibitor U0126

• In vivo using the rat kainate lesion model, RAD140 demonstrated neuroprotective effects in gonadectomized adult male rats

Breast Cancer Research

RAD140 has been investigated for its potential in treating AR/ER+ breast cancer:

• In AR/ER+ breast cancer patient-derived xenografts (PDX), RAD140 substantially inhibited tumor growth as a single agent

• Coadministration of RAD140 and the CDK4/6 inhibitor palbociclib showed improved efficacy

• RAD140 activates AR in breast cancer cells while suppressing the ER pathway, including repression of the ESR1 gene

• A subset of AR-repressed genes associated with DNA replication was suppressed with RAD140 treatment

Clinical Trial Data

A first-in-human phase 1 study in 22 heavily pretreated patients with ER+/HER2- metastatic breast cancer provided key insights :

• Dose levels: 50 mg (n=6), 100 mg (n=13), and 150 mg (n=3) once daily

• Half-life: 44.7 hours, supporting once-daily dosing

• MTD: Maximum tolerated dose of 100 mg/day

• Clinical benefit rate: 18.2% at 24 weeks

• Biomarker evidence: SHBG decreased in 18/18 patients, PSA increased in 16/20 patients

• AR engagement: Confirmed by paired baseline and on-treatment tumor biopsies

Pharmacokinetic Properties

RAD140 demonstrates favorable pharmacokinetic characteristics:

• Good oral bioavailability in rats (27-63%) and monkeys (65-75%)

• Elimination half-life of 45-60 hours, allowing once-daily dosing

• High stability (t1/2 > 2 h) in incubations with rat, monkey, and human microsomes

Important Safety Considerations for Research

Hepatotoxicity Reports

Multiple case reports have documented liver injury associated with non-medical RAD140 use :

• A 29-year-old male developed jaundice and elevated liver enzymes after three months of RAD140 use (20 mg/day), with total bilirubin reaching 42 mg/dL

• Liver ultrasound revealed hepatic steatosis and F1 fibrosis; symptoms resolved after discontinuation

• Recovery period may take 3-5 months for liver biochemistries to normalize

• Patients typically require close outpatient monitoring as the recovery period can be prolonged

Clinical Trial Adverse Events

In the phase 1 clinical trial, the most frequent (>10%) treatment-emergent adverse events included :

• Elevated AST (59.1%)

• Elevated ALT (45.5%)

• Elevated total blood bilirubin (27.3%)

• Vomiting, dehydration, decreased appetite, and weight loss (27.3% each)

• Grade 3/4 TEAEs occurred in 72.7% of patients, including AST/ALT elevations and hypophosphatemia (22.7% each)

Hormonal Effects

• In gonadally intact male cynomolgus monkeys, RAD140 suppressed testosterone levels by approximately 50% (from ~600-800 ng/dL to ~200-300 ng/dL)

• SHBG levels decreased in 100% of patients in clinical trials

• PSA levels increased in 80% of patients

Lipid Profile Effects

Changes in serum lipids, including triglycerides, LDL cholesterol, and HDL cholesterol, have been observed in preclinical studies .

Regulatory Status

• RAD140 is on the World Anti-Doping Agency list of prohibited substances

• It is not approved for any medical use and is not available as a licensed pharmaceutical drug as of 2023

• The FDA has issued official warnings and concerns about SARM usage

How to Use Pharmaqo US RAD 140 for Research Applications

For research professionals utilizing Pharmaqo US – RAD 140 (TESTOLONE) in laboratory settings, understanding proper protocols is essential for experimental validity.

• Form & Potency: This product is supplied as a lyophilized powder in a sterile vial containing Pharmaqo US RAD 140. (Specific vial potency would typically be listed on product packaging.)

• Solubility:

  • Soluble in DMSO at ≥100 mg/mL

  • For biological assays, first dissolve in DMSO, then dilute to aqueous buffer using appropriate co-solvents

• In Vitro Formulation Example: For 1 mL working solution, add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL normal saline .

• Storage:

  • Powder form: Stable for ≥1 year when stored at -20°C

  • In solution: Store at -80°C for up to 6 months or -20°C for up to 1 month

  • Avoid repeated freeze-thaw cycles; aliquot into working volumes

• In Vitro Applications:

  • Cell culture studies have used RAD140 at concentrations ranging from 0-300 nM for neuroprotection assays

  • In cultured neurons, 100 nM RAD140 (1 hour pretreatment) guards against apoptotic insults

  • For androgen receptor activation studies, concentrations should be determined empirically through dose-response experiments

• In Vivo Applications:

  • Animal studies have utilized RAD140 at doses ranging from 0.03-10 mg/kg body weight

  • Immature castrated rat studies used 0.03-0.3 mg/kg for 11 days to assess tissue effects

  • For neuroprotection studies, doses should be determined based on specific experimental models

• Important Research Considerations:

  • For research use only; not for human consumption

  • Not approved for therapeutic use by FDA, EMA, or other regulatory authorities

  • Must be used under approved research protocols with appropriate oversight

  • Monitor liver function parameters in relevant animal models

  • Consider hormonal effects when designing experimental protocols

Note: This product is intended for research use only and is not for human consumption. Not for diagnostic or therapeutic use in humans.

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Who Pharmaqo US RAD 140 Is For

This research-grade compound is designed for scientific researchers, laboratory professionals, and research institutions conducting studies in androgen receptor biology, muscle physiology, cancer research, and neuroprotection. It is particularly valuable for those investigating tissue-selective androgen modulation, AR signaling pathways, and potential therapeutic applications in muscle wasting and breast cancer. If you are a research professional dedicated to advancing scientific understanding through rigorous investigation, and you require high-quality research compounds for your work, Pharmaqo US RAD 140 is your essential research tool. Check our competitive Pharmaqo US RAD 140 price UK research professionals appreciate.

Order Pharmaqo US RAD 140 (TESTOLONE) Online from uksteroidshop.co.uk

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Frequently Asked Questions for Researchers

What is RAD140 and what is its mechanism of action?
RAD140 (Testolone, Vosilasarm) is a selective androgen receptor modulator (SARM) that binds selectively to androgen receptors with high affinity (Ki = 7 nM) . It acts as an agonist in select tissues such as skeletal muscle and bone, where it promotes anabolic effects, while demonstrating partial agonist or antagonist activity in tissues like the prostate . This tissue selectivity is a key characteristic distinguishing SARMs from traditional androgens.

What is the half-life of RAD140?
RAD140 has an elimination half-life of approximately 45-60 hours in humans . This extended half-life supports once-daily dosing in research applications and clinical protocols.

What are the primary research applications for RAD140?
RAD140 has been extensively studied for research applications including: 1) investigating androgen receptor biology and tissue-selective modulation, 2) studying anabolic effects in muscle and bone, 3) exploring potential therapeutic applications in AR/ER+ breast cancer, 4) investigating neuroprotective properties and MAPK signaling pathways, and 5) understanding the molecular mechanisms of selective androgen receptor modulation .

What is the purity and solubility of Pharmaqo US RAD 140?
Pharmaqo US RAD 140 exceeds >98% purity as determined by HPLC analysis. The compound is soluble in DMSO at ≥100 mg/mL . For biological assays, first dissolve in DMSO, then dilute to aqueous buffer using appropriate co-solvents as described in formulation protocols .

What safety concerns should researchers be aware of?
Multiple case reports have documented hepatotoxicity associated with non-medical RAD140 use, including elevated liver enzymes, jaundice, and hepatic steatosis . Clinical trial data showed frequent elevations in AST (59.1%), ALT (45.5%), and total bilirubin (27.3%) . RAD140 also suppresses testosterone levels, reduces SHBG, and affects lipid profiles . The compound is not approved for human use and should only be used in research settings with appropriate safety precautions.

Is the Pharmaqo US RAD 140 you sell authentic?
Absolutely. We are a UK-based supplier with a reputation to protect in the research community. We guarantee that every vial of Pharmaqo US RAD 140 sold on uksteroidshop.co.uk is 100% genuine, sourced directly from authorised Pharmaqo US distributors and stored correctly under controlled temperatures to maintain its premium quality assurance. When you purchase Pharmaqo US RAD 140 from us for your research, authenticity is guaranteed.

What is the typical Pharmaqo US RAD 140 price UK for research purposes?
We pride ourselves on offering competitive pricing for all our premium research compounds. The Pharmaqo US RAD 140 price UK listed on our site reflects the superior research-grade quality of this selective androgen receptor modulator while ensuring excellent value for research facilities and scientific professionals. Check the product page for current pricing and multi-buy offers for laboratories.