Description
Buy Pharmaqo US SR9009 (STENABOLIC) UK | REV-ERB Agonist for Metabolic Research
Pharmaqo US – SR9009 (STENABOLIC) – Available Now in the UK
For researchers and scientists investigating metabolic regulation, circadian biology, and exercise physiology, Pharmaqo US – SR9009 (STENABOLIC) delivers a premium research-grade compound for laboratory use. SR9009, also known as Stenabolic, is a synthetic compound that acts as an agonist of the REV-ERB family of nuclear receptors, with a half-maximum inhibitory concentration (IC50) of 670 nM for REV-ERB-α and 800 nM for REV-ERB-β . Research has demonstrated that SR9009 exhibits diverse biological activities, including improving exercise tolerance and controlling skeletal muscle mass in animal models . Now available from uksteroidshop.co.uk, your trusted UK-based supplier, you can access this premium research compound with the assurance of Pharmaqo US quality.
Whether you’re conducting metabolic research in Birmingham, studying circadian regulation in Manchester, or investigating exercise physiology in Glasgow or Edinburgh, we deliver nationwide. Research facilities across London, Leeds, Liverpool, Bristol, Nottingham, Sheffield, Cardiff, and Belfast trust us for their laboratory compound needs. Experience the quality and consistency required for serious scientific investigation.
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Premium Research-Grade Quality
Pharmaqo US is renowned for producing high-quality research-grade compounds. Every batch of Pharmaqo US – SR9009 (STENABOLIC) meets stringent quality benchmarks, ensuring you receive a product that delivers consistent, reliable performance for your research applications. When you purchase Pharmaqo US SR9009 from us, you’re investing in premium quality for your laboratory work.
REV-ERB Agonist Mechanism
SR9009 functions as a specific REV-ERB-α/β agonist, exhibiting direct and reversible binding with a Kd of 800 nM for REV-ERB-α and showing excellent selectivity over a panel of 46 other nuclear receptors . The compound potently increases REV-ERB-dependent repressor activity and reduces BMAL1 mRNA in cell-based assays .
Research Applications
SR9009 has been extensively studied for its effects on:
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Exercise capacity: Activation of REV-ERB-α by SR9009 in mice increases exercise capacity by increasing mitochondria in skeletal muscle
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Metabolic regulation: Studies demonstrate SR9009 can improve exercise tolerance and lower blood lipid levels in animal models
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Circadian biology: The compound alters the expression pattern of core clock genes and metabolic genes in liver, skeletal muscle, and adipose tissue
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Cell proliferation: Research indicates SR9009 has REV-ERB-independent effects on cell proliferation and metabolism
Authenticity Guaranteed
The market is flooded with counterfeit products, but uksteroidshop.co.uk guarantees you receive Genuine Pharmaqo US – SR9009 (STENABOLIC). We source directly from authorised Pharmaqo US distributors to ensure you are getting the real deal, not a dangerous substitute. Every vial is verified authentic.
UK Stock Availability
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Key Research Findings on SR9009 (Stenabolic)
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REV-ERB Agonist Activity: SR9009 acts as an agonist of REV-ERB-α and REV-ERB-β, with IC50 values of 670 nM and 800 nM respectively . It exhibits direct and reversible binding to REV-ERB-α with a Kd of 800 nM .
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Exercise Capacity Enhancement: Research demonstrates that activation of REV-ERB-α by SR9009 in mice increases exercise capacity by increasing mitochondria in skeletal muscle . Recent 2024 studies confirm that SR9009 improves exercise tolerance in normal mice in vivo .
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Metabolic Effects: A 7-day administration of SR9009 (100 mg/kg, i.p., b.i.d.) in mice causes significant weight and fat loss with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian patterns . In diet-induced obese mice, SR9009 treatment decreased fat mass and markedly improved dyslipidemia and hyperglycemia .
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REV-ERB-Independent Actions: Landmark research from Penn Medicine published in PNAS demonstrated that SR9009 can decrease cell viability, rewire cellular metabolism, and alter gene transcription in cells completely depleted of REV-ERBs . This finding has important implications for interpreting previous studies attributing all effects solely to circadian clock mechanisms.
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Blood-Brain Barrier Permeability: SR9009 has been shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties in research models .
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Exercise Tolerance in Pathological Models: In hyperlipidemic mice, SR9009 not only improved exercise tolerance but also lowered blood lipid levels, with some analogues displaying stronger hypoglycaemic activity than the parent compound .
Important Pharmacokinetic Considerations for Research
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Bioavailability: Research data from mouse studies using a dose of 1 mg/kg indicates that SR9009 has an oral bioavailability of approximately 2.2% with a half-life of less than one hour . Some sources indicate it has no oral bioavailability , though forum discussions note that increasing the dose may produce effects despite low bioavailability .
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Half-Life: Studies demonstrate SR9009 has a short half-life of about 2 hours , implying its effects are temporary and dosage may need to be spread throughout the day for continuous effects in research models .
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Dosing Considerations in Animal Models: Research studies have utilized various dosing regimens, including 100 mg/kg intraperitoneal administration twice daily (b.i.d.) . Forum discussions among researchers note that effective protocols may require multiple daily doses due to the compound’s short half-life .
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Metabolic Stability: SR9009 can decrease cell viability, rewire cellular metabolism, and alter gene transcription in a time-dependent manner in laboratory settings .
How to Use Pharmaqo US SR9009 (STENABOLIC) for Research Applications
For research professionals utilizing Pharmaqo US SR9009 (STENABOLIC) in laboratory settings, understanding proper protocols is essential for experimental validity.
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Form & Concentration: This product is supplied in liquid form suitable for research applications. (Specific concentration would typically be listed on product packaging.)
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Storage: Store in a cool, dark place as specified on product packaging. Following reconstitution, aliquot and freeze (-20°C) for extended stability. Stock solutions are stable for up to 6 months at -20°C .
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Handling: Standard laboratory handling procedures should be observed. Following reconstitution, aliquot and freeze to maintain stability .
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In Vitro Applications: Research has utilized SR9009 in various cell culture models, including mouse hepatocytes treated with SR9009 for 8 hours to study gene expression changes .
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In Vivo Applications: Animal studies have employed dosing regimens including 100 mg/kg intraperitoneal administration twice daily . Doses should be converted appropriately for different animal models based on body surface area.
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Important Research Considerations: Researchers should be aware that SR9009 has been shown to have REV-ERB-independent effects on cell proliferation and metabolism . Control experiments should account for potential off-target effects when interpreting experimental results.
Note: This product is intended for research use only and is not for human consumption. Not for diagnostic or therapeutic use in humans.
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Who Pharmaqo US SR9009 Is For
This research-grade compound is designed for scientific researchers, laboratory professionals, and research institutions conducting studies in metabolic regulation, circadian biology, exercise physiology, and related fields. It is particularly valuable for those investigating REV-ERB biology, mitochondrial function, and metabolic disease models. If you are a research professional dedicated to advancing scientific understanding through rigorous investigation, and you require high-quality research compounds for your work, Pharmaqo US SR9009 is your essential research tool. Check our competitive Pharmaqo US SR9009 price UK research professionals appreciate.
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Frequently Asked Questions for Researchers
What is the mechanism of action of SR9009?
SR9009 is a synthetic compound that acts as an agonist of the REV-ERB family of nuclear receptors, specifically REV-ERB-α and REV-ERB-β, with IC50 values of 670 nM and 800 nM respectively . It exhibits direct and reversible binding to REV-ERB-α with a Kd of 800 nM and shows excellent selectivity over a panel of 46 other nuclear receptors . However, landmark research has demonstrated that SR9009 also has REV-ERB-independent effects on cell proliferation and metabolism, as it can decrease cell viability, rewire cellular metabolism, and alter gene transcription in cells completely depleted of REV-ERBs .
What is the half-life and bioavailability of SR9009 in research models?
Research data from mouse studies using a dose of 1 mg/kg indicates that SR9009 has a short half-life of about 2 hours and an oral bioavailability of approximately 2.2% . Some sources indicate it has no oral bioavailability . The short half-life implies its effects are temporary in laboratory settings, and dosage may need to be spread throughout the day for continuous effects in research models .
What dosing regimens have been used in published research?
Published studies have utilized various dosing regimens. In one study, a 7-day administration of SR9009 at 100 mg/kg intraperitoneal (i.p.) twice daily (b.i.d.) caused significant weight and fat loss in C57BL6 mice . Another study used 100 mg/kg i.p., b.i.d. for 30 days in diet-induced obese mice . Researchers should convert doses appropriately for different animal models based on body surface area and consider the compound’s short half-life when designing experimental protocols.
Has SR9009 been shown to have effects independent of REV-ERB?
Yes, groundbreaking research from Penn Medicine published in PNAS demonstrated that SR9009 can decrease cell viability, rewire cellular metabolism, and alter gene transcription in two different cell types completely depleted of REV-ERBs . The senior author noted that “these findings have important implications because some of the previous studies concluded it was the circadian clock that was effecting metabolism or cell growth, through these compounds” and that “needs to be reconsidered, as our study shows these compounds work on something other than this clock factor” .
What are the primary research applications for SR9009?
SR9009 has been extensively studied for research applications including: 1) investigating the regulation of exercise ability and glycolipid metabolism , 2) studying REV-ERB biology and circadian rhythm regulation , 3) exploring metabolic effects including fat loss and glucose regulation , 4) investigating effects on skeletal muscle oxidative capacity and mitochondrial biogenesis , and 5) studying cell proliferation and metabolism in various cell types .
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Absolutely. We are a UK-based supplier with a reputation to protect in the research community. We guarantee that every vial of Pharmaqo US SR9009 sold on uksteroidshop.co.uk is 100% genuine, sourced directly from authorised Pharmaqo US distributors and stored correctly to maintain its premium quality assurance. When you purchase Pharmaqo US SR9009 from us for your research, authenticity is guaranteed.
What is the typical Pharmaqo US SR9009 price UK for research purposes?
We pride ourselves on offering competitive pricing for all our premium research compounds. The Pharmaqo US SR9009 price UK listed on our site reflects the superior research-grade quality of this REV-ERB agonist while ensuring excellent value for research facilities and scientific professionals. Check the product page for current pricing and multi-buy offers for laboratories.
