Buy Pharmaqo US GW501516 (Cardarine) UK | PPARδ Agonist for Metabolic Research

Pharmaqo US – GW501516 (CARDARINE) – Available Now in the UK

For researchers and scientists investigating metabolic regulation, exercise physiology, and nuclear receptor signaling, Pharmaqo US – GW501516 (CARDARINE) delivers a premium research-grade PPARδ agonist. GW501516 is a small molecule drug that acts as a potent and selective agonist of the peroxisome proliferator-activated receptor delta (PPARδ), with an EC50 of approximately 1 nM and >1000-fold selectivity over other PPAR subtypes . Originally investigated for the treatment of metabolic disorders including dyslipidemia, obesity, and type-1 diabetes, this compound has been extensively studied for its effects on fatty acid oxidation, exercise endurance, and skeletal muscle metabolism . Now available from uksteroidshop.co.uk, your trusted UK-based supplier, you can access this premium research compound with the assurance of Pharmaqo US quality.

Whether you’re conducting metabolic research in Birmingham, studying exercise physiology in Manchester, or investigating PPARδ signaling pathways in Glasgow or Edinburgh, we deliver nationwide. Research facilities across London, Leeds, Liverpool, Bristol, Nottingham, Sheffield, Cardiff, and Belfast trust us for their advanced research compound needs. Experience the quality and consistency required for serious scientific investigation.

Why Choose uksteroidshop.co.uk for Pharmaqo US GW501516

Premium Research-Grade Quality

Pharmaqo US is renowned for producing high-quality research-grade compounds. Every batch of Pharmaqo US – GW501516 (CARDARINE) meets stringent quality benchmarks, with purity exceeding >98% by HPLC analysis . When you purchase Pharmaqo US GW501516 from us, you’re investing in premium quality for your laboratory work.

Potent PPARδ Agonist Activity

GW501516 is a potent and subtype-selective PPARδ agonist with a Ki of 1.1 nM in human PPARδ binding assays . It displays >1,000-fold selectivity over other PPAR subtypes (PPARα and PPARγ), making it an invaluable tool for studying PPARδ-specific biological processes .

Extensive Research Background

GW501516 has been the subject of extensive preclinical research, with studies demonstrating its effects on:

• Running endurance: GW501516 treatment for 3 weeks significantly enhanced running distance in both sedentary and trained mice

• Fatty acid oxidation: The compound promotes fatty acid oxidation in skeletal muscle and adipose tissue, reducing glucose utilization during exercise

• Muscle fiber reprogramming: PPARδ activation induces a shift toward oxidative type I muscle fibers with greater endurance capacity

• Lipid metabolism: GW501516 increases expression of the reverse cholesterol transporter ABCA1 and induces apolipoprotein A1-specific cholesterol efflux

Authenticity Guaranteed

The market is flooded with counterfeit products, but uksteroidshop.co.uk guarantees you receive Genuine Pharmaqo US – GW501516 (CARDARINE). We source directly from authorised Pharmaqo US distributors to ensure you are getting the real deal, not a dangerous substitute. Every vial is verified authentic.

UK Stock Availability

Forget waiting weeks for international parcels. We maintain deep UK stock ready to ship, meaning your order is processed and dispatched promptly from within the country. When you order Pharmaqo US GW501516 online, it ships from the UK immediately.

Secure Checkout Process

Your privacy and security are our priority. Our secure & private checkout system protects your data, allowing you to complete your transaction with complete peace of mind.

Trusted by Researchers

Join the ranks of research professionals across the UK who rely on us for their laboratory compound needs. We have built our reputation on reliability, product quality, and exceptional service. We are Trusted by UK research facilities nationwide, particularly those conducting metabolic and exercise physiology studies.

Key Product Specifications

• Compound Name: GW501516 (Cardarine, Endurobol)

• IUPAC Name: 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid

• CAS Number: 317318-70-0

• Molecular Formula: C₂₁H₁₈F₃NO₃S₂

• Molecular Weight: 453.5 g/mol

• Purity: >98% (HPLC)

• Physical Form: Powder

• Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)

• Storage: -20°C (stable for ≥1 year as powder)

• Mechanism: PPARδ agonist, EC50 ≈ 1 nM

• Selectivity: >1000-fold over PPARα and PPARγ

Key Research Findings on GW501516

Effects on Exercise Endurance

Research has demonstrated that GW501516 significantly enhances running endurance in animal models. A study in Kunming mice showed that:

• GW501516 treatment for 3 weeks increased exhaustive running distance by 68.6% in sedentary mice and 31.2% in trained mice

• Even 1 week of GW501516 treatment alone improved running distance by 48.6% compared to vehicle control

• GW501516 treatment reduced blood glucose utilization during endurance running and prevented post-exercise lactate accumulation

Metabolic Effects

PPARδ activation by GW501516 drives metabolism toward fatty acid oxidation:

• The compound promotes specific consumption of fatty acids while reducing glucose utilization during exercise

• GW501516 increases serum unsaturated fatty acid levels, especially polyunsaturated fatty acids, an effect enhanced when combined with training

• Palmitic acid (the predominant fatty acid in vivo) increased by 92% in GW501516-treated sedentary mice and 282% in trained treated mice

Skeletal Muscle Effects

Studies in animal models of cardiac dysfunction show:

• GW501516 administration (5 mg/kg/day for 4 weeks) improved running endurance in mice with left ventricular dysfunction

• Treatment increased oleic acid oxidation levels in skeletal muscle, accompanied by transcriptional changes including increased CPT1 expression

• The compound protects against cytokine-induced decreases in fatty acid oxidation

Mechanism of Action

• GW501516 binds directly to PPARδ with high affinity (Ki = 1.1 nM)

• Activation of PPARδ regulates genes involved in fatty acid transport, β-oxidation, and mitochondrial respiration

• The compound reprograms muscle fibers toward more oxidative phenotypes with greater endurance capacity

Important Safety Considerations for Research

Carcinogenicity

GW501516 has been classified as a carcinogenic agent in some databases . Studies have shown an increase in cancer in rats, which significantly impacted its clinical development . This important safety consideration must be carefully evaluated when designing research protocols.

Regulatory Status

• GW501516 reached maximum clinical trial phase II for investigational indications including dyslipidemia and metabolic disorders

• Development was discontinued due to safety concerns observed in preclinical studies

• The compound is not approved for human use by regulatory agencies including the FDA and EMA

Research Applications

Despite safety concerns, GW501516 remains a valuable research tool for:

• Studying PPARδ biology and signaling pathways

• Investigating mechanisms of fatty acid oxidation and lipid metabolism

• Understanding skeletal muscle adaptation and exercise physiology

• Exploring metabolic regulation in disease models

Handling Precautions

• Use appropriate personal protective equipment (PPE) when handling

• Conduct all work in properly ventilated areas or fume hoods

• Dispose of waste according to institutional and regulatory guidelines

• Store securely and limit access to authorized research personnel only

How to Use Pharmaqo US GW501516 for Research Applications

For research professionals utilizing Pharmaqo US – GW501516 (CARDARINE) in laboratory settings, understanding proper protocols is essential for experimental validity.

• Form & Potency: This product is supplied as a powder in a sterile vial containing Pharmaqo US GW501516. (Specific vial potency would typically be listed on product packaging.)

• Solubility:

  • Soluble in DMSO up to 40 mg/ml

  • Soluble in Ethanol up to 20 mg/ml

  • For biological assays, first dissolve in DMSO or ethanol, then dilute to aqueous buffer

• Storage:

  • Powder form: Stable for ≥1 year when stored at -20°C

  • In solution: Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

  • Avoid repeated freeze-thaw cycles; aliquot into working volumes

• In Vitro Applications:

  • Cell culture studies have used GW501516 to treat differentiated L6 myotubes to test effects on free fatty acid uptake

  • Used in organoid culture medium to study effects on stem cell self-renewal

  • Applied as a component in defatting medium for primary human hepatocyte culture

  • Typical working concentrations should be determined empirically through dose-response experiments

• In Vivo Applications:

  • Animal studies have utilized GW501516 at 5 mg/kg body weight per day administered via gavage

  • Studies have used treatment durations ranging from 1-4 weeks to assess effects on running endurance and metabolism

  • Doses should be converted appropriately for different animal models based on body surface area

• Important Research Considerations:

  • For research use only; not for human consumption

  • Not approved for therapeutic use by FDA, EMA, or other regulatory authorities

  • Must be used under approved research protocols with appropriate oversight

  • Consider carcinogenicity findings when designing long-term studies

  • Monitor appropriate safety parameters in animal models

Note: This product is intended for research use only and is not for human consumption. Not for diagnostic or therapeutic use in humans.

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Who Pharmaqo US GW501516 Is For

This research-grade compound is designed for scientific researchers, laboratory professionals, and research institutions conducting studies in metabolic regulation, exercise physiology, PPARδ biology, and related fields. It is particularly valuable for those investigating fatty acid oxidation, muscle fiber typing, mitochondrial biogenesis, and the molecular mechanisms of exercise adaptation . If you are a research professional dedicated to advancing scientific understanding through rigorous investigation, and you require high-quality research compounds for your work, Pharmaqo US GW501516 is your essential research tool. Check our competitive Pharmaqo US GW501516 price UK research professionals appreciate.

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Frequently Asked Questions for Researchers

What is GW501516 and what is its mechanism of action?
GW501516 (also known as Cardarine or Endurobol) is a small molecule drug that acts as a potent and selective agonist of peroxisome proliferator-activated receptor delta (PPARδ) . It binds to PPARδ with high affinity (Ki = 1.1 nM) and displays >1000-fold selectivity over other PPAR subtypes . Activation of PPARδ regulates genes involved in fatty acid oxidation, mitochondrial respiration, and skeletal muscle metabolism .

What are the primary research applications for GW501516?
GW501516 has been extensively studied for research applications including: 1) investigating the mechanisms of PPARδ signaling and biology, 2) studying fatty acid oxidation and lipid metabolism, 3) exploring exercise physiology and skeletal muscle adaptation, 4) investigating metabolic regulation in disease models including obesity, diabetes, and dyslipidemia, and 5) understanding muscle fiber type reprogramming and mitochondrial biogenesis .

What is the purity and solubility of Pharmaqo US GW501516?
Pharmaqo US GW501516 exceeds >98% purity as determined by HPLC analysis . The compound is soluble in DMSO (up to 40 mg/ml) and Ethanol (up to 20 mg/ml) . For biological assays, first dissolve in DMSO or ethanol, then dilute to aqueous buffer.

How should GW501516 be stored for research use?
The powder form is stable for ≥1 year when stored at -20°C . Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months . Avoid repeated freeze-thaw cycles; aliquot into working volumes.

What safety concerns should researchers be aware of?
GW501516 has been classified as a carcinogenic agent in some databases . Studies have shown an increase in cancer in rats, which significantly impacted its clinical development . The compound is not approved for human use and should only be used in research settings with appropriate safety precautions. Researchers should consider these findings when designing long-term studies and interpret results accordingly.

Is the Pharmaqo US GW501516 you sell authentic?
Absolutely. We are a UK-based supplier with a reputation to protect in the research community. We guarantee that every vial of Pharmaqo US GW501516 sold on uksteroidshop.co.uk is 100% genuine, sourced directly from authorised Pharmaqo US distributors and stored correctly under controlled temperatures to maintain its premium quality assurance. When you purchase Pharmaqo US GW501516 from us for your research, authenticity is guaranteed.

What is the typical Pharmaqo US GW501516 price UK for research purposes?
We pride ourselves on offering competitive pricing for all our premium research compounds. The Pharmaqo US GW501516 price UK listed on our site reflects the superior research-grade quality of this PPARδ agonist while ensuring excellent value for research facilities and scientific professionals. Check the product page for current pricing and multi-buy offers for laboratories.